RNA Details
Disease Name
kidney diseases
Tissue
kidney
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
qRT-PCR; dual-luciferase reporter assay
Target
NOTCH1;JAGGED1
Pathway
NOTCH SIGNALING PATHWAY
PubMed ID
Title
Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
Year
2012
Function
Hypoxia-induced decrease of miR-34a expression could promote diabetic nephropathies in renal tubular epithelial cells by directly targeting Notch1 and Jagged1.